Kathryn co-organized the second Systems Immunology conference at Cold Spring Harbor Laboratory. Alas, due to the Covid-19 crisis, the conference was virtual this year. The conference included three days of amazing cross-disciplinary research.
Our lab was featured in today’s Yale Daily News: Understanding our immune systems: Yale lab observes how macrophages respond to conflicting signals. The article describes some of Andrés and Ilana’s work that was recently published in Nature Communications.
Our lab was featured in today’s Yale Engineering Magazine: ‘Cellular Chatter’: Researchers Aim to Decode Communications Within a Tumor. The article describes our lab’s work with the Marcus Bosenberg lab and our recent grant funded by the National Cancer Institute.
Our lab was recently awarded a $2.8M grant from the National Cancer Institute to support our work with the Bosenberg lab through the Yale Cancer Center. We are, of course, enormously grateful for NCI’s support for this important work in which we’ll be modeling and evaluating cytokine signaling related to cancer immunotherapy.
Kathryn gave the SBME Seminar at the University of British Columbia, School of Biomedical Engineering (Vancouver Campus). She spoke about our work on single-cell analysis of macrophage heterogeneity.
Content here Kathryn spoke at Pitt and CMU in their joint Ph.D. Program in Computational Biology and the Department of Computational and Systems Biology Seminar. She discussed our group’s work exploring regulation of HIV latency with single-cell systems biology.
Andrés successfully defended his thesis, “Analysis of macrophage polarization: single-cell responses in controlled and tumor microenvironments”. Congrats!
Our lab was featured in today’s Yale Daily News: Yale researchers root out latent HIV viruses. The article describes Arvind and Victor’s work on HIV latency that was recently published in Scientific Reports.
Linda successfully defended her thesis, “Data-Driven Analysis of Phospho-Signaling Network Responses Enables Latent HIV-Infected T Cell Targeting”. Congrats!
Elise Bullock was awarded a slot on Yale’s NIH T32 Training grant supporting the Integrated Graduate Program in Physical and Engineering Biology.
Amanda Alexander was awarded a Graduate Student Research Fellowship from the National Science Foundation.
In “Last Barrier to a Cure HIV”, Yale Scientific Magazine speaks about HIV latency with Kathryn and she describes our lab’s work on HIV “shock and kill”.
Our lab was featured in this month’s Yale Engineering Magazine and today’s Yale News: Yale researchers bring an engineering approach to systems biology efforts. The article describes some of our work with the Levchenko, Fan, and Murrell labs at Yale.
Ramesh’s device is featured in SciTechDaily.
Ramesh designed a simple microfluidic device to trap an array of single T cells and then they used it to image noisy activation of latent HIV.
Qiong and Yao compared data from isolated single-cell assays to data from populations of cells to demonstrate that paracrine signaling is essential for stimulating a full LPS secretion response in macrophages. Markus applied data-driven modeling of the single-cell data to identify the most crucial paracrine signals regulating the response.
Linda, Victor, and Arvind presented posters at the recent Keystone conference, Mechanisms of HIV Persistence: Implications for a Cure.
Kathryn was selected to receive the 2015 NSF CAREER Award for our group’s project, “Reverse Engineering the Inflammatory Signaling Network from Single-Cell Data.” The award provides $500,000 in funding to researchers who exemplify the role of teacher-scholars. The CAREER Award is the NSF’s most prestigious award for junior faculty.
This project examines why genetically identical macrophages — the first responders in the immune system — vary in how strongly they respond to the presence of pathogens by secreting pro-inflammatory “danger signals.” Using state-of-the-art experimental tools for single-cell analysis, our group is identifying the sources of heterogeneity from transcription to secretion of proteins used for intracellular communication. These experiments are used to fit a mathematical model of signaling, cytokine secretion, and diffusion fit to single-cell data so that we can make predictions about emergent population behavior.
Kathryn was featured on Fusion’s “genius” segment. In this short video she describes the counterintuitive ‘shock and kill’ method to curing HIV.